Rosalind Franklin University of Medicine and Science
发明人:
Perbal, Bernard,Riser, Bruce L.
申请号：
AU2006203851
公开号：
AU2006203851B8
申请日:
2006.01.10
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The present invention discloses a role of CCN3 in diseases associated with the overexpression of CCN2, which include but are not limited to kidney disease, fibrosis, and cancer. The full length CCN3 protein or fragments thereof or isoforms (or combinations) of CCN3 are involved in these diseases. The isolated and purified CCN3 protein or its fragments or isoforms (or combinations) of CCN3 can be potentially used in the treatment or prevention of these diseases by regulating the expression and/or activity of the CCN2 protein. The level of CCN3 in tissue or body fluids can also be used to predict, diagnose and/or follow the progression of diseases as well as to determine the effectiveness of therapeutic intervention.
