A drug delivery system to deliver two or more medicaments operable through a syringe (5) and a single dispense interface (140). The device comprises a housing defining a primary reservoir (70), the primary reservoir containing a liquid. The device further includes a dosing mechanism (10) operably connected to the primary reservoir. Still further, the device includes a secondary reservoir for a medicament comprising at least one drug agent configured for fluid communication to the single dispense interface. Yet still further, the device includes a single dispense interface configured for fluid communication with the primary reservoir and the secondary reservoir. A single activation of the dosing mechanism causes liquid from the primary reservoir and a non-user settable dose of the medicament to be expelled through the single dispense interface.
