The present invention discloses curcumin monosulphate and its salts for treatment of cancer. The present invention also discloses the process for synthesis of curcumin monosulphate and its salts. Curcumin monosulphate and its salts have anticancer property which is effective against liver and colorectal cancer. The present invention deals with an anticancer formulation for curcumin monosulphate and its salts.