Substituted quinolone derivatives, or pharmaceutically acceptable salts or stereoisomers thereof, and pharmaceutical compositions and use thereof

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专利权人:

SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;JINAN UNIVERSITY

发明人:

Ke Ding,Meiyu Geng,Li Tan,Jian Ding,Zhang Zhang,Jing Ai,Xiaomei Ren,Donglin Gao,Zhengchao Tu,Xiaoyun Lu,Dongmei Zhang

申请号：

US15752896

公开号：

US10683278B2

申请日:

2016.08.18

申请国别(地区):

US

年份:

2020

代理人:

摘要：

Provided are a substituted quinolone derivative as shown by formula (I), or a pharmaceutically acceptable salt and a prodrug molecule thereof, and a pharmaceutical composition thereof, as well as the use of same in preparing drugs for the prevention and treatment of a tumor. The quinolone derivative, salt, prodrug molecule, and pharmaceutical composition thereof can be used as a protein kinase inhibitor, which is effective in inhibiting the activity of AXL protein kinase, and is capable of inhibiting the proliferation, migration and invasion of various tumor cells； and can be used in the preparation of anti-tumor drugs, especially drugs for treating hyperproliferative diseases such as a tumor in human beings and other mammals.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/