Disclosed are efficacious pharmaceutical compositions in the form of intraocular suspensions comprising an anti-angiogenic compound in a therapeutically effective amount and a polyethylene glycol having a molecular weight of at least 2000, preferably at least 3000. The compositions are preferably for treatment of ocular disorders, such as diabetic retinopathy, age-related macular degeneration, macular edema, uveitis, and geographic atrophy.