Listeria-based immunogenic compositions comprising a Wilms tumor protein (WT1) antigen and methods for treating and vaccinating cancer and inducing an immune response against cancer in a subject are provided. A recombinant fusion polypeptide or chimeric polypeptide comprising a Wilms tumor protein antigen, a nucleic acid encoding such a chimeric polypeptide or fusion polypeptide, a recombinant comprising such a chimeric or fusion polypeptide or such a nucleic acid Bacteria or Listeria strains as well as cell banks containing such recombinant bacteria or Listeria strains are also provided herein. Also provided herein are methods of producing such chimeric or fusion polypeptides, such nucleic acids, and such recombinant bacteria or Listeria strains. Also provided are immunogenic compositions, pharmaceutical compositions, and vaccines comprising such chimeric or fusion polypeptides, such nucleic acids, or such recombinant bacteria or Listeria strains. A method of inducing an anti-WT1 immune response in a subject using such a recombinant chimeric or fusion polypeptide, nucleic acid, recombinant bacterium or Listeria strain, immunogenic composition, pharmaceutical composition, or vaccine； Methods for inducing an anti-WT1-expressing tumor or anti-WT1-expressing cancer immune response in a subject, methods for treating a WT1-expressing or WT1-related tumor or cancer in a subject, and methods for preventing a WT1-expressing or WT1-related tumor or cancer in a subject And methods of protecting a subject against WT1 expression or a WT1-related tumor or cancer are also provided.ウィルムス腫瘍タンパク質（ＷＴ１）抗原を含むリステリアベースの免疫原性組成物ならびに対象においてがんを処置する、及びがんに対してワクチン接種する、及びがんに対する免疫応答を誘導する方法を提供する。ウィルムス腫瘍タンパク質抗原を含む組換え融合ポリペプチドまたはキメラポリペプチド、そのようなキメラポリペプチドまたは融合ポリペプチドをコードする核酸、そのようなキメラポリペプチドもしくは融合ポリペプチドまたはそのような核酸を含む組換え細菌またはＬｉｓｔｅｒｉａ株、ならびにそのような組換え細菌またはＬｉｓｔｅｒｉａ株を含む細胞バンクも本明細書で提供する。そのようなキメラポリペプチドまたは融合ポリペプチド、そのような核酸、及びそのような組換え細菌またはＬｉｓｔｅｒｉａ株を生成する方法も本明細書で提供する。そのようなキメラポリペプチドもしくは融合ポリペプチド、そのような核酸、またはそのような組換え細菌もしくはＬｉｓ
