Marie-Gabrielle Braun,Keira Garland,Emily Hanan,Hans Purkey,Steven T. Staben,Robert Andrew Heald,Jamie Knight,Calum Macleod,Aijun Lu,Guosheng Wu,Siew Kuen Yeap
申请号：
US15258175
公开号：
US10065970B2
申请日:
2016.09.07
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Described herein are tricyclic compounds with phosphoinositide-3 kinase (PI3K) modulation activity or function having the Formula I structure:or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of using such PI3K modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon PI3K dysregulation.
