ANTICORPS DU RECEPTEUR ANTI-IL-6

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专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人:

IGAWA, TOMOYUKI,SAKURAI, MIKA,KOJIMA, TETSUO,TACHIBANA, TATSUHIKO,SHIRAIWA, HIROTAKE,TSUNODA, HIROYUKI,MAEDA, ATSUHIKO

申请号：

CA2700498

公开号：

CA2700498C

申请日:

2008.09.26

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The present inventors succeeded in discovering specific amino acid mutationsin thevariable region, framework region, and constant region of TOCILIZUMAB, andthis enables toreduce immunogenicity risk and the heterogeneity originated from disulfidebonds in the hingeregion, as well as to improve antigen binding activity, pharmacokinetics,stability under acidicconditions, and stability in high concentration preparations.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/