This invention relates to compositions of chimeric and humanized antibodies that bind to the human CTLA4 molecule and their use in cancer immunotherapy and for reduction of autoimmune side effects compared to other immunotherapeutic agents.本發明係關於與人類CTLA4分子結合之嵌合及人類化抗體之組合物及其在癌症免疫療法中及用於與其他免疫治療劑相比減少自體免疫副作用之用途。