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Novel 2-aminooxazolines as TAAR1 ligands for CNS diseases
专利权人:
エフ.ホフマン-ラ;アーゲー;ロシュ;エフ.ホフマン-ラ ロシュ アーゲー
发明人:
ガレイ,グウィード,グレープケ,ツビンデン・カトリン,ノークロス,ロジャー,シュタルダー,ヘンリ,ガレイ,グウィード,グレープケ,ツビンデン・カトリン,ノークロス,ロジャー,シュタルダー,ヘンリ
申请号:
JP2009547642
公开号:
JP5248528B2
申请日:
2008.01.23
申请国别(地区):
JP
年份:
2013
代理人:
摘要:
The invention relates to compounds of formula I wherein X, Y, R<;SUP>;1<;/SUP>;, R<;SUP>;2<;/SUP>;, and n are as defined herein or to a pharmaceutically suitable acid addition salt thereof. The invention also relates to pharmaceutical compositions containing such compounds and methods for the treatment of diseases related to the biological function of the trace amine associated receptors, which diseases include depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder, stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson's disease, neurodegenerative disorders, Alzheimer's disease, epilepsy, migraine, substance abuse and metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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