Ian MacLachlan,Adam Judge,Snorri S. Thorgeirsson,Yun-Han Lee
申请号：
US12903558
公开号：
US08227443B2
申请日:
2010.10.13
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides compositions comprising nucleic acids that target CSN5 gene expression and methods of using such compositions to silence CSN5 gene expression. More particularly, the present invention provides unmodified and chemically modified interfering RNA molecules which silence CSN5 gene expression and methods of use thereof, e.g., for treating cell proliferative disorders such as cancer. The present invention also provides nucleic acid-lipid particles that target CSN5 gene expression comprising an interfering RNA molecule, a cationic lipid, a non-cationic lipid, and optionally a conjugated lipid that inhibits aggregation of particles.
