A physiology sensing patch device includes a physiology patch unit, a wireless transmission unit and a thermoelectric power generation unit. An operation method of the physiology sensing patch device includes: arranging the thermoelectric power generation unit to connect with the physiology patch unit and the wireless transmission unit attaching the thermoelectric power generation unit to a skin area for generating a voltage value supplying the voltage value to the physiology patch unit and the wireless transmission unit operating the physiology patch unit to measure at least one physical data and further operating the wireless transmission unit to transmit the physical data to a main receiver or a host.一種節能生理檢測貼片裝置包含一生理檢測貼片單元、一無線通訊單元及一溫差發電單元。一種生理檢測貼片操作方法包含:提供該溫差發電單元連接於該生理檢測貼片單元及無線通訊單元;利用該溫差發電單元貼附於一受測者之皮膚表面,以便利用體溫與環境溫度之間產生一電壓值;將該溫差發電單元之電壓值供應至該生理檢測貼片單元及無線通訊單元;及利用該生理檢測貼片單元檢測該受測者之至少一生理資料,利用該無線通訊單元進行無線傳輸該生理檢測貼片單元所檢測之生理資料至一接收主機。1‧‧‧節能生理檢測貼片裝置10‧‧‧生理檢測貼片單元11‧‧‧無線通訊單元12‧‧‧身分辨識單元2‧‧‧接收主機
