The present invention relates, in part, to compositions and methods for enhancement of an immune response by partial mTOR inhibition, e.g., with low, immune enhancing, doses of an mTOR inhibitor, such as RAD001.本發明部分關於藉由部分mTOR抑制,例如使用低及免疫增強劑量之mTOR抑制劑(諸如RAD001),來增強免疫反應的組合物及方法。