VRTALA, SUSANNE,STUMVOLL, SABINE,GRONLUND, HANS,GROTE, MONIKA,VANGELISTA, LUCA,PASTORE, ANNALISA,SPERR, WOLFGANG R.,VALENT, PETER,KRAFT, DIETRICH,VALENTA, RUDOLF
申请号：
CA2387260
公开号：
CA2387260C
申请日:
2000.10.24
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The invention relates to a hypoallergenic immunogenic molecule derived fromthe Phl p 6 allergen, wherein the Phl p 6 molecule has an N-terminal and/or C-terminal deletion which makes the molecule at least substantially lack IgEbinding capacity. The invention also relates to a hypoallergenic immunogeniccombination of molecules derived from the Phl p 6 allergen, comprising: (i) aPhl p 6 molecule having an N-terminal deletion which makes the molecule atleast substantially lack IgE binding capacity, and (ii) a Phl p 6 moleculehaving a C-terminal deletion which makes the molecule at least substantiallylack IgE binding capacity, which two molecules together encompass the completesequence of Phl p 6. The invention further relates to the use of thehypoallergenic immunogenic molecule or molecule mixture in hyposensitizationand diagnosis.
