The present invention relates to method for preparing liposome-based constructs comprising a peptide, particularly an antigenic peptide, or interest modified through hydrophobic moieties reconstituted in liposomes and to the antigenic constructs obtained with said method. The invention further relates to the use of said constructs for the therapeutic and diagnostic use in the treatment of diseases and disorders, which are caused by or associated with proteopathy such as Alzheimer's Disease.本發明係關於製備基於脂質體之構築體之方法，該等構築體包含在脂質體中重構之經由疏水性部分修飾之所關注肽，尤其抗原性肽，及關於利用該方法獲得之抗原性構築體。本發明進一步關於該等構築體在治療蛋白質構象病(proteopathy)引起或相關疾病及病症(諸如阿茲海默氏病(Alzheimer's Disease))中之治療性及診斷性用途。
