ZHU GAOZHONG,LOWE KRIS,SHAHROKH ZAHRA,PAN JING,WRIGHT TERESA LEAH,CALIAS PERICLES,FAHRNER RICK,CHRISTIAN JAMES
申请号：
NZ60586311
公开号：
NZ605863A
申请日:
2011.06.25
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed is a stable formulation for intrathecal administration comprising an iduronate-2-sulfatase (I2S) protein, salt, and a polysorbate surfactant. Further disclosed is a stable intrathecal formulation for treating Hunters Syndrome comprising an iduronate-2-sulfatase (I2S) protein at a concentration ranging from approximately 1-300 mg/ml, NaCl at a concentration of approximately 154 mM, polysorbate 20 at a concentration of approximately 0.005%, and a pH of approximately 6.0.
