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ABUSE-RESISTANT ORAL DOSAGE FORMS AND METHOD OF USE THEREOF
专利权人:
ELITE LABORATORIES; INC.
发明人:
MEHTA, ATUL M.
申请号:
EP04759447
公开号:
EP1615623A4
申请日:
2004.04.08
申请国别(地区):
EP
年份:
2012
代理人:
摘要:
An opioid-antagonist oral dosage form which does not release a therapeutically effective amount of the opioid antagonist when the oral dosage form is orally administered to a human being, but whereby a physical alteration of the oral dosage form results in a release of the therapeutically effective amount of the opioid antagonist. An embodiment of the oral dosage form includes an opioid-antagonist layer coated onto a biologically inert pellet, and a non-releasing membrane coated onto the opioid-antagonist layer. Optionally, the oral dosage form can also include an opioid agonist, such that a method of preventing the abuse of an oral dosage form of an opioid agonist is provided by forming the oral dosage form including an opioid agonist and an opioid antagonist.
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