JUN KUAI,KEN DOWER,JEFFREY L. FELDMAN,DEBRA D. PITTMAN,MOLTREYEE CHARTTERJEE-KISHORE,DAVID WINKLER,LIH-LING LIN,SCOTT ALAN JELINSKY,CARA WILLIAMS
申请号：
BRPI0806680
公开号：
BRPI0806680A2
申请日:
2008.01.16
申请国别(地区):
BR
年份:
2015
代理人:
摘要：
The present invention provides methods of treating inflammatory diseases/disorders in a subject by inhibiting/antagonizing TREM-1 expression/activity/signal transduction and/or DAP12/TyroBP expression and/or activity. Methods of detecting the presence of inflammatory disease in a subject by detecting TREM-1 and/or DAP12/TyroBP expression and/or activity in the subject or a sample obtained therefrom, wherein increased expression or activity is indicative of the inflammatory disease are also included. The present invention further provides methods for assessing the efficacy of a TREM-1-modulating agent administered to a patient by detecting levels of secreted phosphoprotein 1 (SPP1) and/or one or more other biomarkers in the patient or in a sample from the patient.
