GUSAROVA, VIKTORIA,MURPHY, ANDREW J.,GROMADA, JESPER,GUO, DAYONG
申请号：
CA3012693
公开号：
CA3012693A1
申请日:
2017.02.03
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of an Angiopoietin- like protein 8 (ANGPTL8) gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous ANGPTL8 locus so that said non-human animals express a human ANGPTL8 polypeptide.
