optimized early-late promoter combined with repeated vaccination favors antigen cytotoxic cell response in replication-deficient recombinant virus vaccines

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专利权人:

BAVARIAN NORDIC A/S

发明人:

JÜRGEN HAUSMANN,KAREN BAUR,KAY BRINKMANN

申请号：

BRPI1009138

公开号：

BRPI1009138A2

申请日:

2010.03.11

申请国别(地区):

BR

年份:

2016

代理人:

摘要：

The present invention relates to a replication deficient recombinant virus encoding at least one antigen and/or antigenic epitope, wherein expression of said antigen and/or antigenic epitope is regulated by a transcriptional control element comprising at least two elements driving early expression of said antigen and/or antigenic epitope and the use of said replication deficient recombinant virus as medicament or vaccine.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/