Claridge, Stephen William,Raeppel, Franck,Saavedra, Oscar Mario,Zhan, Lijie,Vaisburg, Arkadii
申请号:
AU2006343808
公开号:
AU2006343808B2
申请日:
2006.05.19
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
The invention relates to compounds of formula A, and their use for inhibiting the VEGF receptor KDR and the HGF receptor c-met Pn preferred structures of formula A, A is S, A=A=CH, Z is O, S, S(O) or NR, Ar is phenyl, and G includes a nitrogen linker to Ar The groups D, G, and R are as defined herein The invention also provides compositions and methods for treating cell proliferative diseases and conditions Examples of the diseases include breast cancer, lung cancer, colon cancer, rectal cancer, bladder cancer, leukemia and renal