Roderick A. Hyde,Wayne R. Kindsvogel,Gary L. McKnight
申请号：
US13827960
公开号：
US09499855B2
申请日:
2013.03.14
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Embodiments described herein relate to methods, devices, and computer systems thereof for the derivation of T CAR libraries (Universal Subject or Individual Subject) for personalized treatment of disease in a subject. In certain embodiments, differential screening of normal and diseased tissue expression data is utilized to determine disease-specific antigens and thereby generate T CAR cells reactive to such antigens to form a disease-specific library. In certain embodiments, determination of the most effective T CAR clones from the disease-specific library is based on the subjects own disease-specific antigens. In certain embodiments, a subject is treated with a therapeutically effective amount of T CAR clones.
