Provided are bioactive compositions and metabolites derived from Bacillus and particularly Bacillus megaterium cultures responsible for controlling pests as well as their methods of use for controlling pests. Further provided are pesticidal Bacillus megaterium strains.Se proveen composiciones y metabolitos bioactivos derivados de cultivos de Bacillus y particularmente Bacillus megaterium responsable del control de plagas así como sus métodos para el uso en el control de plagas. Además se proveen cepas plaguicidas de Bacillus megaterium.