PROBLEM TO BE SOLVED: To provide a novel compound which has strong beta amyloid 40 and beta amyloid 42 production inhibitory activity and is useful as a therapeutic agent and/or a prophylactic agent for psychoneurotic diseases that are caused by beta amyloid and typified by Alzheimers disease.SOLUTION: This invention relates to a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. [In the formula, X1 represents CQ1 or the like, X2 represents CQ2 or the like, X3 represents CQ3 or the like, Q1, Q2 and Q3 each independently represent a hydrogen atom or the like, Y represents C0-6 alkylene which may be substituted, Z represents a single bond or -(a 4-9-membered nitrogen-containing saturated heterocyclic divalent group which may be substituted)-W-, W represents -(CH2)n- or the like, A represents aryl or the like, R1 represents C1-6 alkyl or the like, R2 represents C1-6 alkoxy or the like, R3 represents a hydrogen atom or the like, and n represents an integer of 0-4].COPYRIGHT: (C)2013,JPO&INPIT【課題】強いベータアミロイド40及びベータアミロイド42産生抑制作用を有し、アルツハイマー病に代表されるベータアミロイドに起因する精神神経疾患の治療剤及び/又は予防剤として有用な新規化合物の提供。【解決手段】式(I)の化合物又はその製薬学的に許容される塩[式中、X1はCQ1等を表し、X2はCQ2等を表し、X3はCQ3等を表し、Q1、Q2及びQ3は各々独立して水素原子等を表し、Yは置換されていてもよいC0-6アルキレンを表し、Zは単結合又は-(置換されていてもよい4~9員の含窒素飽和複素環の2価基)-W-を表し、Wは-(CH2)n-等を表し、Aはアリール等を表し、R1はC1-6アルキル等を表し、R2はC1-6アルコキシ等を表し、R3は水素原子等を表し、nは0~4の整数を表す] 。【選択図】 なし
