SLUSHER, BARBARA,VOLSKY, DAVID,NEDELCOVYCH, MIKE,HOLLINGER, KRISTEN
申请号：
CA2994162
公开号：
CA2994162A1
申请日:
2016.07.29
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The presently disclosed subject matter relates to methods, uses, and pharmaceutical compositions comprising at least one glutamine antagonist, or a prodrug or analog thereof, for the treatment of cognitive deficits, such as those associated with neurological or neurodegenerative disorders, psychiatric or mood disorders, and HIV-associated neurocognitive disorders (HAND)). The presently disclosed subject matter provides supporting PK and biomarker data. These data predict the use of glutamine antagonists (or their prodrugs or analogs) for the treatment of cognitive deficits in general, and specifically for cognitive deficits associated with neurological or neurodegenerative disorders, psychiatric or mood disorders, and HAND.
