Method for development and use of minimally polarized functional cell microaggregate units using LGR4, LGR5 and LGR6 expressing epithelial stem cells in tissue applications
Herein, wound treatment applications, tissue engineering, cell therapy applications, regenerative medicine applications, medical / therapeutic applications, preferably in combination with a delivery vehicle / substrate / support / scaffold for direct application Providing a construct that is a multi-cell minimally polarized graft of microaggregates comprising leucine-rich repeat-containing G protein-coupled receptor (LGR) expressing cells for tissue healing applications, immunotherapy applications and tissue transplantation therapy applications .本明細書において、好ましくは、直接適用のための送達媒体／基材／支持体／スカフォールドと結合させたものである、創傷治療適用、組織工学、細胞療法適用、再生医療適用、医療／治療適用、組織治癒適用、免疫療法適用および組織移植治療適用のためのロイシンリッチリピート含有Ｇタンパク質共役受容体（ＬＧＲ）発現細胞を含む微細凝集塊の多細胞の最小限分極移植片である構築物を提供する。
