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КОМПОЗИЦИИ И СПОСОБЫ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ЗЛОКАЧЕСТВЕННЫХ НОВООБРАЗОВАНИЙ
专利权人:
ЮТиАй ЛИМИТЕД ПАРТНЕРШИП (CA)
发明人:
САНТАМАРИЯ Пере (CA)
申请号:
RU2013121571/15
公开号:
RU2013121571A
申请日:
2011.11.11
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A method of treating a tumor or malignant neoplasm of the object, comprising administering entity complex tumor antigen / MHC / co-stimulatory molecule is operably linked to a nanoparticle having a diameter of from about 1 to about 100 nm, in an amount sufficient for producing a population of antigen-specific antitumor T -cells specific to the tumor or malignancy, making the tumor or malignancy exposed lecheniyu.2. A method according to claim 1, wherein said antineoplastic The accumulated population of T cells is antigen-specific antitumor effector T kletki.3. A method according to claim 2, further comprising the administration of antigen / MHC / nanoparticle without costimulatory molekul.4. The method of claim 1, wherein the diameter of the nanoparticles ranges from about 5 nm to about 25 nm.5. A method according to claim 1 or 3 wherein the antigen-specific anti-tumor T-cells are CD8 + T kletki.6. A method according to claim 1 or 3, wherein the MHC represent MHC class II.7. A method according to claim 1 or 3 wherein the antigen-specific anti-tumor T-cells are CD4 + T-kletki.8. A method according to claim 1 or 3, wherein the tumor is a malignant opuhol.9. The method of use and / or development of populations antigenspetsifchnyh antitumor T cells in the object, which comprises administering to a subject the complex tumor antigen / MHC / co-stimulatory molecule / nanoparticle in an amount and at a sufficient rate to increase and / or development of these populations, where the nanoparticle diameter is from about 1 to about 100 nm.10. The method of claim 9, wherein the produced antigen-specific antitumor T cells pre1. Способ лечения опухоли или злокачественного новообразования у объекта, включающий введение объекту комплекса опухолевый антиген/МНС/ко-стимулирующая молекула, функционально связанного с наночастицей, имеющий диаметр от около 1 до около 100 нм, в количестве, достаточном для наработки популяции антигенспецифичных противоопухолевых Т-клеток, специфичных к
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