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Composition and method for detection of pre-metastatic sites
专利权人:
发明人:
申请号:
EP08168802.0
公开号:
EP2106804A3
申请日:
2008.11.11
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
Disclosed are a radio-immunoconjugate for diagnosis and treatment of cancer or metastasis and development of metastasis inhibitory formulations using the same. More particularly, the present invention provides a radio-immunoconjugate as material indicating a metastatic cancer that has antibody marked with any lanthanum radionuclide and/or gamma, beta or alpha ray emitting radioisotopes targeting a vascular endothelial growth factor receptor (VEGFR). Such a radio-immunoconjugate is advantageous in that it maintains structural stability of a protein and immune activity thereof and is effectively adsorbed to the surface of vascular endothelial cells, thereby being useful as a pre-metastatic site detection factor. When the radio-immunoconjugate is administered to an animal model with a cancer, the radio-immunoconjugate is accumulated in cancer tissues, and therefore, is useful for development of radioactive metastasis inhibitory formulations.
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