An auto-injector for receiving a primed syringe includes: a plunger driver for coupling to a plunger head of the syringe when the syringe is fitted within the auto-injector, and configured to drive a plunger into a barrel of the syringe, wherein the plunger driver positioned on the auto-injector such that it is below the plunger head when the syringe is primed and fitted within the auto-injector.
