XIAO HE,JASON A. DUQUETTE,TIMOTHY D. CUSHING,YOUNGSOOK SHIN,JULIA WINSLOW LOHMAN
申请号:
MX2012011387
公开号:
MX2012011387A
申请日:
2011.04.01
申请国别(地区):
MX
年份:
2013
代理人:
摘要:
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.Se describen heteroarilos bicíclicos sustituidos y composiciones que los contienen, para el tratamiento de inflamación general, artritis, enfermedades reumáticas, osteoartritis, trastornos inflamatorios del intestino, trastornos inflamatorios del ojo, trastornos de la vejiga inestables o inflamatorios, psoriasis, dolencias de la piel con componentes inflamatorios, afecciones inflamatorias crónicas, incluyendo pero no restringidas a enfermedades autoinmunitarias tales como lupus eritematoso sistémico (SLE), miastenia gravis, artritis reumatoide, encefalomielitis diseminada aguda, púrpura trombocitopénica idiopática, esclérosis múltiple, síndrome de Sjoegren y anemia hemolítica autoinmunitaria, afecciones alérgicas incluyendo todas las formas de hipersensibilidad. La presente invención también permite métodos