KIM, JIN SUN,KIM, DAE JIN,LEE, SANG HYUN,JUNG, SUNG YOUB,KWON, SE CHANG
申请号：
PE2015000594
公开号：
PE20151420A1
申请日:
2013.11.06
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
This is an integral part of the prevention or treatment of diabetes, diabetes or diabetic complications, which includes oxygen analysis as a positive start. The invention also relates to a procedure for the treatment of diabetes, obesity or diabetic complications, including an effective drug analysis of an object. Compared with the local hydroxybutyric acid simulator, oxygen multi module analysis has a strong ability to activate GLP-1 receiver and glucon receiver. Oxygen nucleic acid modulation analysis induced expansion of B cells and increased insulin secretionReduce the glucose content in the blood, and increase the glucose content due to the high fat and high calorie diet. Oxygen modulation analysis results in a reduction in body weight and dietary intake to improve insulin sensitivity and maintain blood glucose levels that cannot be controlled due to insulin resistance at normal levels. Therefore, it can be effectively used to prevent or treat diabetes and related diseases.Referida a una composicion para prevenir o tratar diabetes, diabesidad o complicaciones diabeticas, que comprende un analogo de oxintomodulina como principio activo. La invencion tambien se refiere a un procedimiento para tratar diabetes, obesidad o complicaciones diabeticas, que comprende administrar una cantidad farmaceuticamente efectiva de un analogo de oxintomodulina a un sujeto. El analogo de oxintomodulina tiene una alta capacidad de activar el receptor GLP-1 y el receptor glucagon, en comparacion con la oxintomodulina nativa. El analogo de oxintomodulina induce la expansion de celulas beta y aumenta la secrecion de insulina, reduciendo de ese modo los niveles de glucosa en sangre que se incrementaron debido a una dieta elevada en grasas y elevada en calorias. El analogo de oxintomodulina induce reducciones en el peso corporal e ingesta de dieta para mejorar la sensibilidad a la insulina y permitir que los niveles de glucosa en sangre, que no son controlados debido a la resistencia a l
