Devices, apparatuses, systems, and methods for improved clog resistant orifices in medical devices and tubes are provided. A medical tube will comprise a tubular wall having one or more clog resistant orifices. The clog resistant orifices have an outwardly flared orifice wall so as to minimize the occurrence of clogging. The outward flaring, and in some cases inward tapering relative to the outer surface of the tubular wall, can minimize tension and compression forces from forming within the orifice. These forces can otherwise maintain a clog in position within the orifice. The portions of the tubular wall adjacent the orifices may also be more flexible than the remainder of the tubular wall, allowing such portions to bend under pressure or suction to facilitate the shearing away of any clog from the orifice.