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HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE
专利权人:
Daniel J. CAPON
发明人:
Daniel CAPON
申请号:
US14776489
公开号:
US20160024226A1
申请日:
2014.03.14
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention provides compounds producing compounds having the structure (I). Wherein A is a first polypeptide component of the compound; wherein C is a second polypeptide component of the compound, which polypeptide component comprises consecutive amino acids which (i) are identical to a stretch of consecutive amino acids present in a chain of an Fc domain of an antibody; (ii) bind to an Fc receptor, and (iii) have at their N-terminus a sequence selected from the group consisting of a cysteine, selenocysteine, CP, CPXCP (where X=P, R, or S), CDKTHTCPPCP, CVECPPCP, CCVECPPCP and CDTPPPCPRCP, wherein B is a chemical structure linking A and C; wherein the dashed line between B and C represents a peptidyl linkage; wherein the solid line between A and B represents a nonpeptidyl linkage comprising the structure (II).
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