Michael K. Schultz,Frances L. Johnson,Somya Kapoor,Dongyoul Lee,Mengshi Li
申请号：
US16312846
公开号：
US20190321495A1
申请日:
2017.06.25
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The invention provides compositions, kits and methods to treat a hyperproliferative disorder with an agent that increases expression of MCR1 and an MCR1 ligand. The invention also provides a method of treating drug-resistant melanoma, comprising administering an MCR1 ligand to a patient in need thereof. The present invention also provides in certain embodiments a melanoma-targeting conjugate comprising Formula (I): T-L-X wherein T is a MCR1 ligand, L is a linker, and X an anti-cancer composition, for the therapeutic treatment of a hyperproliferative disorder. The present invention also provides methods, kits and uses of the conjugate of Formula (I).
