NOVEL MUTANT L-ASPARAGINASES

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专利权人:

发明人:

SONAWANE AVINASH,MEHTA RANJIT KUMAR

申请号：

IN418/KOL/2013

公开号：

IN2013KO00418A

申请日:

2013.04.16

申请国别(地区):

IN

年份:

2016

代理人:

摘要：

[0001] The present invention relates to non-naturally occurring L-Asparaginases mutants particularly Type II Escherichia coli L- asparaginase (EcA) mutants comprising at least one mutation in the amino-acid sequence of wild-type EcA, wherein such mutation causes the mutants to induce significantly lesser immunogenicity, higher stability and higher cytotoxicity against leukemic cells as compared to wild-type EcA. The present invention also provides use of the EcA mutants as anti-leukemic agents for treatment of Acute Lymphoblastic Leukemia (ALL) in a subject in need thereof.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/