The present invention relates to a fusion protein comprising p53 protein and p15 protein bound to each other, and a pharmaceutical composition containing the same for prevention or treatment of cancer. According to an embodiment of the present invention, the pharmaceutical composition can prevent or treat cancer effectively. The fusion protein may additionally contain one or more components selected from the group consisting of in vitro stabilization protein, membrane transfer sequence (MTS) domain, nucleus-cytoplasm signal domain, and in vivo stabilization protein.COPYRIGHT KIPO 2015p53 단백질 및 p15 단백질이 결합된 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 약학 조성물에 관한 것이다. 일 구체예에 따른 약학 조성물에 따르면, 효과적으로 암의 예방 또는 치료가 가능하다.