QUARK PHARMACEUTICALS, INC.;THE UNITED STATES OF AMERICA REPRESENTED BY THE UNITED STATES DEPARTMENT OF VETERAN'S AFFAIRS
发明人:
申请号：
IL21680411
公开号：
IL216804D0
申请日:
2011.12.06
申请国别(地区):
IL
年份:
2012
代理人:
摘要：
The present invention relates to oligonucleotide compounds for use in methods for treating chronic kidney disease (CKD) including methods for preventing or delaying onset of CKD and methods for preventing exacerbation and progression of CKD. In particular embodiments, the invention provides methods for treating a subject at risk of developing CKD comprising administering to the subject a composition comprising a) a therapeutically effective amount of at least one oligonucleotide compound which inhibits the expression of a human target gene associated with the kidney disease chosen from p53 and CASP2； and b) a pharmaceutically acceptable excipient or carrier, or mixtures thereof, thereby reducing the risk of CKD in the subject.
