TOSK, INC.; INC.;TOSK;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人:
GARLAND, WILLIAM,FRENZEL, BRIAN,KARG, TRAVIS,WIPKE, TODD,KONOPELSKI, JOSEPH
申请号：
EP09719744
公开号：
EP2265274A4
申请日:
2009.03.02
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
Methods are provided for using methotrexate (MTX) in which reduced host toxicity is observed. Aspects of the methods include administering to a subject an effective amount of MTX in conjunction with a MTX toxicity-reducing adjuvant, such as a 2,2&prime；-anhydropyrimidine, a derivative thereof or a uridine phosphorylase inhibitor. Also provided are compositions that find use in practicing embodiments of the invention. The methods and compositions find use in a variety of applications, including the treatment of a variety of different disease conditions.
