Hong Shen,Patrick S. Stayton,Anthony Convertine,Kenny K. Tran
申请号：
US14152876
公开号：
US20140161893A1
申请日:
2014.01.10
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Core-shell polymer blend particles are described. The particles include a pH-responsive polymeric shell and a pH-irresponsive polymeric core. The core can include a biodegradable hydrolysable polymer and the shell can include a pH-responsive copolymer that can include constitutional units that are cationic and/or anionic at physiological pH. The core-shell polymer blend particles can allow the controlled delivery of agents into a plurality of distinct intracellular compartments.
