SOLUBILIZED CAPSULE FORMULATION OF 1,1-DIMETHYLETHYL [(1S)-1-{[(2S,4R)-4-(7-CHLORO-4METHOXYISOQUINOLIN-1-YLOXY)-2-({ (1R,2S)-1-[(CYCLOPROPYLSULFONYL)CARBAMOYL]-2-ETHENYLCYCLOPROPYL} CARBAMOYL)PYRROLIDIN-1-YL]CARBONYL}-2,2-DIMETHYLPROPYL]CARBAMATE .

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专利权人:

BRISTOL-MYERS SQUIBB HOLDINGS IRELAND

发明人:

Robert Kevin PERRONE

申请号：

MX2014013220

公开号：

MX358545B

申请日:

2013.04.30

申请国别(地区):

MX

年份:

2018

代理人:

摘要：

The present disclosure includes various embodiments directed to a solubilized capsule formulation of asunaprevir, 1,1-dimethylethyl [(1S)-1-{[(2S,4R)-4-(7-chloro-4methoxyisoquinolin-1-yloxy)-2-({ (1R,2S)-1-[(cyclopropylsulfonyl)carbamoyl]-2-ethenylcyclopropyl} carbamoyl)pyrr olidin-1-yl]carbonyl}-2,2-dimethylpropyl]carbamate, and to methods including asunaprevir.La presente descripción incluye varias modalidades que se refieren a una formulación en cápsula solubilizada de asunaprevir, [(1S)-1-{[(2S,4R)-4-(7-cloro-4metoxiisoquinolin-1-ilo xi)-2-({(1R,2S)-1-[(ciclopropilsulfonil)carbamoil]-2-etenilciclop ropil}carbamoil)pirrolidin-1-il]carbonil}-2,2-dimetilpropil] carbamato de 1,1-dimetiletilo, y a métodos que incluyen asunaprevir.

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