The present invention relates to the compounds or its pharmaceutically acceptable salt with chemical formula (I), and wherein R1 to R5 has any meaning defined in foregoing specification； It is related to their preparation method； Be related to comprising they pharmaceutical composition and they treatment cell proliferation disorders in purposes.本發明涉及具有化學式(I)的化合物或其藥學上可接受的鹽，其中R1至R5具有在上文說明書中所定義的任意含義；涉及它們的製備方法；涉及包含它們的藥物組合物以及它們在治療細胞增殖性障礙中的用途。
