Ignacio MARTINEZ,Zachary Garo ARMEN,Christine CEZAR,Barry Andrew MARTIN,Maier Steve AVENDANO AMADO
申请号：
US16480053
公开号：
US20190365853A1
申请日:
2018.01.24
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Provided herein are methods and compositions useful for human health, e.g., for targeting one or more microorganisms resident in a host insect (e.g., arthropod, e.g., insect, e.g., pathogen vector), the modulation resulting in a decrease in the fitness of the host. The invention features a composition that includes a modulating agent (e.g., phage, peptide, small molecule, antibiotic, or combinations thereof) that can alter the host's microbiota in a manner that is detrimental to the host. By disrupting microbial levels, microbial activity, microbial metabolism, or microbial diversity, the modulating agent described herein may be used to decrease the fitness of a variety of insects that carry vector-borne pathogens that cause disease in humans.
