Disclosed is a composition derived from fresh Ficus leaf juice, wherein said composition is Ficus Serum Fraction. Further disclosed is a process for making a Ficus cell serum fraction composition, said process comprising: a. separating ficus cell juice from clean, fresh, un-wilted ficus leaves to obtain fresh ficus cell juice, wherein no exogenous liquid is added prior or during said separating； b. filtering said fresh ficus cell juice to obtain fiber-free cell juice； and c. fractionating said fiber-free cell juice to obtain Ficus Serum Fraction, wherein said fractionating comprises: (1) removing chlorophyll from said fiber-free cell juice to obtain Supernatant I； (2) removing pigments and proteins from Supernatant I to form Ficus Serum Fraction.
