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6,7 - DIHYDROIMIDAZO
专利权人:
发明人:
KAWANO YOSHIKAZU,HARAGUCHI YOSHIKAZU,SASAKI HIROFUMI,UEMATSU YUKITAKA,TSUBOUCHI HIDETSUGU,YATA HIROMI,SHIMIZU HIROSHI,KOHASHI KAZUHO,ITOTANI MOTOHIRO,TAI KUNINORI,TAKEMURA ISAO,HAYASHI MIKAYO,HASHIZUM
申请号:
IN8138/DELNP/2013
公开号:
IN2013DN08138A
申请日:
2013.09.17
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
The present invention provides a novel 6,7-dihydroimidazo[2,l-b][l,3]oxazine compound that has excellent bactericidal action against tubercle bacilli, multidrug-resistant tubercle bacilli, and atypical acid-fast bacilli. Specifically, the present invention provides a compound represented by Formula (1): or a salt thereof, wherein R1 represents tetrahydroisoquinolyl, tetrahydroquinolyl, tetrahydrobenzoazepinyl, benzoxazolyl, benzothiazolyl, indolyl, isoindolinyl, naphthyl, quinolyl, phenyl, biphenylyl, or pyridyl, these groups being optionally substituted, the phenyl, biphenylyl, and pyridyl represented by R1 each being substituted dir ectly or via a linker with at least one group selected from the group consisting of tetrahydropyridyl, diazepanyl, diazabicyclo - heptanyl, tetrahydrotriazolopyrazinyl, tetrahydroimidazopyrazmyl, azabicyclooctanyl, oxazolyl, piperazinyl, piperidyl, thiazolyl, and the like, each of these groups being optionally substituted; and R2 represents hydrogen or lower alkyl. The present invention further provides a pharmaceutical composition containing the above.
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