The invention relates to a nutritional composition comprising (a) at least 18 en % of proteinaceous matter (b) at least 12 wt % of leucine, based on total proteinaceous matter (c) a lipid fraction comprising at least a &omega-3 polyunsaturated fatty acid selected from the group of eicosapentaenoic acid, docosahexaenoic acid, eicosatetraenoic acid and docosapentaenoic acid (d) an immune modulator for improving the immune function in a mammal, preferably a human.