EDWARDS, Simon David,ARMER, Richard Edward,KIMBERLEY, Meriel Ruth,KHAN, Nawaz Mohammed
申请号：
DK09785362
公开号：
DK2310357T3
申请日:
2009.07.20
申请国别(地区):
DK
年份:
2019
代理人:
摘要：
Compounds of formula (I) and pharmacologically acceptable salts and pro-drugs thereof wherein: Ar1 and Ar2 are aryl or heteroaryl； a is 0 to 5； R1 is alkyl, halogen, haloalkyl, alkoxy, haloalkoxy, alkoxycarbonyl, carboxyl, hydroxyl, amino, monoalkylamino, dialkylamino, nitro, acylamino, alkoxycarbonylamino, alkylsulphonyl, alkylsulphonylamino or cyano and, where a is greater than 1, each substituent R1 may be the same or different； b is 0 to 5； R2 is alkyl, halogen, haloalkyl, haloalkoxy, alkoxy, alkoxycarbonyl, carboxyl, hydroxyl, amino, monoalkylamino, dialkylamino, nitro, acylamino, alkoxycarbonylamino, alkylsulphonyl, alkylsulphonylamino or cyano and where b is greater than 1, each substituent R2 may be the same or different； V is selected from the group consisting of (CR3aR3b)pCON(R3b)X and (CR3aR3b)pN(R3b)CO(X), wherein said groups are in the 3- (meta) or 4- (para) position with respect to the substituent Z； W is selected from the group consisting of NR4a, O, S, S&boxH；O, SO2 and C(R4aR4b)2； X is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, haloalkoxyalkyl, aryloxyalkyl, cycloalkyl, aryl, heteroaryl, polyalkylene glycol, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, alkyl that is substituted with a groups of formula of formula NR8R9 wherein R8 and R9 together with the nitrogen atom to which they are attached form a saturated or partially unsaturated heterocyclic group, carboxyalkyl, alkoxycarbonylalkyl, haloalkoxycarbonylalkyl or aralkyloxycarbonylalkyl； Y and Z are the same or different and each is a substituent selected from the group consisting of (CR5aR5b)n1, C&boxH；O, SO2, C(&boxH；O)NR5a； C(&boxH；O)NR5aSO2 and C&boxH；O(R5aR5b)n2； R3a, R3b, R4a, R4b, R5a and R5b are the same or different and each is selected from the hydrogen, alkyl, cycloalkyl, aryl and heteroaryl； n1 and n2 are the same or different and each is 0 to 2； and p is 0 to 2； are potassium ion channel modulators, making them particularly useful in treating and preventing conditions such as
