TACHDJIAN, CATHERINE,KARANEWSKY, DONALD S.,TANG, XIAO-QING 1,LI, XIAODONG,ZHANG, FENG,SERVANT, GUY,CHEN, QING,DARMOHUSODO, VINCENT,FINE, RICHARD,FOTSING, JOSEPH R.,HAMMAKER, JEFFREY ROBERT,KANG, XINSH
申请号：
SG2012042149
公开号：
SG182179A1
申请日:
2008.06.03
申请国别(地区):
SG
年份:
2012
代理人:
摘要：
MODULATION OF CHEMOSENSORY RECEPTORS AND LIGANDS ASSOCIATED THEREWITH ABSTRACTThe present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.Figure 5
