A preparation comprising a combination of a topical and a systemic antimycotic and a physiologically acceptable lacquer base is suitable for the treatment and prophylaxis of onychomycoses. Preference is given to the use of water-insoluble lacquer preparations and a combination of at least one systemic antimycotic from the group of itraconazole, terbinafine and fluconazole or salts thereof with at least one topical antimycotic from the group of ciclopirox, 6-(2,4,4-trimethylpentyl)-1-hydroxy-4-methyl-2(1H)pyridone, amorolfine and butenafine or salts thereof.
