Systems and methods of producing medical images of a subject are disclosed herein. In one embodiment, structural data and vascular data are acquired from a region of interest in the subject. A filter is generated using structural image data acquired from a second layer and blood flow image data received from a first layer in the region of interest. The filter is applied to vascular image data acquired from a second, deeper layer in the region of interest to form an image of the second layer having reduced tailing artifacts relative to the unfiltered vascular image data.
