BRIGHAM AND WOMEN'S HOSPITAL, INC.;GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
STROBER, WARREN,FUSS, IVAN J.,HELLER, FRANK,BLUMBERG, RICHARD
申请号：
AT10184017
公开号：
AT549064T
申请日:
2002.06.14
申请国别(地区):
AT
年份:
2012
代理人:
摘要：
A method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates IL-13 activity. The invention also provides a method of treating or preventing the inflammatory response of colitis in a subject comprising administering to the subject an effective amount of a substance that modulates NK-T cell activity. The invention also provides for the screening of substances that treat or prevent the inflammatory response of colitis. The substance can be an anti-V±14J±281 antibody fragment, an anti-V±24J±18 antibody fragment, an anti-CD1 antibody fragment that inhibits antigen-presentation to NK-T cells or an anti-IL-13 or an anti-IL-13R± antibody fragment that inhibits IL-13 activity.
